PerioVive is a simple, cost-effective 0.8% hyaluronic acid (HA) in gel formulation for veterinary dental applications.  Hyaluronic acid is a naturally occurring biomaterial that has been proven safe and effective in both humans and dogs for a variety of indications, including dentistry.

HA facilitates periodontal tissue recovery after routine prophylaxis, tooth extraction and gingival surgery. It also works to improve tissue recovery via multiple mechanisms of action to support normal cellular infiltration, stabilize blood clotting, and establish microbial barrier to support tissue healing and recovery. 

Extremely hydrophilic, it absorbs 1000x its weight in water. When contacted with fluids such as water or blood, it increases in viscosity, and on a microscopic level, it binds to specific cell surface receptors enhancing extracellular stability.

Surrogate endpoints suggest halting of progression to more severe periodontal disease and reduction in required tooth extractions. Periodontal applications of HA have shown statistically significant efficacy.

Canine studies demonstrate statistical improvement across a range of endpoints after just a single application.

Decreased:

Gingival recession

Probing pocket depth

Epithelial down growth

Pain post periodontal therapy and tooth extraction

Bleeding on probing

 

Increased:

Bone formation

Cementum formation

Connective tissue attachment

Ligament attachment

Pocket filling post extraction

Rate of wound healing"